257279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3517905..3518742 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag N1705_RS16925 Protein ID WP_219411486.1
Coordinates 3518200..3518742 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID -
Locus tag N1705_RS16920 Protein ID WP_097449025.1
Coordinates 3517905..3518216 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS16895 (3512925) 3512925..3513872 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
N1705_RS16900 (3513894) 3513894..3515885 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
N1705_RS16905 (3515875) 3515875..3516489 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
N1705_RS16910 (3516489) 3516489..3516818 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
N1705_RS16915 (3516830) 3516830..3517720 + 891 WP_000971336.1 heme o synthase -
N1705_RS16920 (3517905) 3517905..3518216 + 312 WP_097449025.1 DUF1778 domain-containing protein Antitoxin
N1705_RS16925 (3518200) 3518200..3518742 + 543 WP_219411486.1 GNAT family N-acetyltransferase Toxin
N1705_RS16930 (3518798) 3518798..3519733 - 936 WP_001297127.1 tetratricopeptide repeat protein -
N1705_RS16935 (3520141) 3520141..3521505 + 1365 WP_001000978.1 MFS transporter -
N1705_RS16940 (3521633) 3521633..3522124 - 492 WP_001138904.1 nucleotide binding protein YajQ -
N1705_RS16945 (3522292) 3522292..3523203 + 912 WP_000705865.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(67-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19831.10 Da        Isoelectric Point: 8.3395

>T257279 WP_219411486.1 NZ_CP104123:3518200-3518742 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGLQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11372.06 Da        Isoelectric Point: 10.4825

>AT257279 WP_097449025.1 NZ_CP104123:3517905-3518216 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAIGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References