Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3483826..3484444 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag N1705_RS16755 Protein ID WP_219411483.1
Coordinates 3484226..3484444 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N1705_RS16750 Protein ID WP_000344800.1
Coordinates 3483826..3484200 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS16740 (3478915) 3478915..3480108 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N1705_RS16745 (3480131) 3480131..3483280 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N1705_RS16750 (3483826) 3483826..3484200 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N1705_RS16755 (3484226) 3484226..3484444 + 219 WP_219411483.1 HHA domain-containing protein Toxin
N1705_RS16760 (3484615) 3484615..3485166 + 552 WP_000102564.1 maltose O-acetyltransferase -
N1705_RS16765 (3485283) 3485283..3485753 + 471 WP_000136192.1 YlaC family protein -
N1705_RS16770 (3485917) 3485917..3487467 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N1705_RS16775 (3487509) 3487509..3487862 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N1705_RS16785 (3488241) 3488241..3488552 + 312 WP_000409911.1 MGMT family protein -
N1705_RS16790 (3488583) 3488583..3489155 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.99 Da        Isoelectric Point: 8.9008

>T257278 WP_219411483.1 NZ_CP104123:3484226-3484444 [Escherichia coli]
MSEKTLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257278 WP_000344800.1 NZ_CP104123:3483826-3484200 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References