Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1430216..1430841 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N1705_RS06950 Protein ID WP_000911330.1
Coordinates 1430443..1430841 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N1705_RS06945 Protein ID WP_000450524.1
Coordinates 1430216..1430443 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS06920 (1426019) 1426019..1426489 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N1705_RS06925 (1426489) 1426489..1427061 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N1705_RS06930 (1427207) 1427207..1428085 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N1705_RS06935 (1428102) 1428102..1429136 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
N1705_RS06940 (1429349) 1429349..1430062 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N1705_RS06945 (1430216) 1430216..1430443 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N1705_RS06950 (1430443) 1430443..1430841 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N1705_RS06955 (1430988) 1430988..1431851 + 864 WP_001267498.1 neutral zinc metallopeptidase -
N1705_RS06960 (1431866) 1431866..1433881 + 2016 WP_219411424.1 tRNA cytosine(34) acetyltransferase TmcA -
N1705_RS06965 (1433955) 1433955..1434653 + 699 WP_000679812.1 esterase -
N1705_RS06970 (1434763) 1434763..1434963 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T257270 WP_000911330.1 NZ_CP104123:1430443-1430841 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT257270 WP_000450524.1 NZ_CP104123:1430216-1430443 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References