257252

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3645721..3646339 Replicon chromosome
Accession NZ_CP104117
Organism Escherichia coli strain USDA-ARS-USMARC-50748

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N1709_RS17910 Protein ID WP_001291435.1
Coordinates 3646121..3646339 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N1709_RS17905 Protein ID WP_000344800.1
Coordinates 3645721..3646095 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1709_RS17895 (3640810) 3640810..3642003 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N1709_RS17900 (3642026) 3642026..3645175 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N1709_RS17905 (3645721) 3645721..3646095 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N1709_RS17910 (3646121) 3646121..3646339 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N1709_RS17915 (3646511) 3646511..3647062 + 552 WP_000102568.1 maltose O-acetyltransferase -
N1709_RS17920 (3647178) 3647178..3647648 + 471 WP_000136192.1 YlaC family protein -
N1709_RS17925 (3647812) 3647812..3649362 + 1551 WP_194300518.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N1709_RS17930 (3649404) 3649404..3649757 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N1709_RS17940 (3650136) 3650136..3650447 + 312 WP_000409911.1 MGMT family protein -
N1709_RS17945 (3650478) 3650478..3651050 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257252 WP_001291435.1 NZ_CP104117:3646121-3646339 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257252 WP_000344800.1 NZ_CP104117:3645721-3646095 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References