257248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2425556..2426082 Replicon chromosome
Accession NZ_CP104117
Organism Escherichia coli strain USDA-ARS-USMARC-50748

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag N1709_RS11995 Protein ID WP_000323025.1
Coordinates 2425795..2426082 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag N1709_RS11990 Protein ID WP_000534858.1
Coordinates 2425556..2425795 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1709_RS11955 (2420624) 2420624..2420749 + 126 WP_260252986.1 hypothetical protein -
N1709_RS11965 (2422002) 2422002..2422306 + 305 Protein_2341 hypothetical protein -
N1709_RS11970 (2422962) 2422962..2424032 + 1071 Protein_2342 ISNCY family transposase -
N1709_RS11975 (2424105) 2424105..2424254 + 150 WP_011443592.1 protein YdfW -
N1709_RS11980 (2424691) 2424691..2425023 - 333 WP_001301033.1 FlxA-like family protein -
N1709_RS11985 (2425226) 2425226..2425531 - 306 WP_001326990.1 protein YdfV -
N1709_RS11990 (2425556) 2425556..2425795 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
N1709_RS11995 (2425795) 2425795..2426082 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
N1709_RS12000 (2426154) 2426154..2426309 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
N1709_RS12005 (2426526) 2426526..2426777 + 252 WP_000980994.1 protein Rem -
N1709_RS12010 (2426844) 2426844..2427122 + 279 WP_012304870.1 hypothetical protein -
N1709_RS12015 (2427124) 2427124..2428173 + 1050 WP_001265198.1 DUF968 domain-containing protein -
N1709_RS12020 (2428187) 2428187..2428939 + 753 WP_001047135.1 antitermination protein -
N1709_RS12025 (2429217) 2429217..2429306 - 90 WP_120795389.1 hypothetical protein -
N1709_RS12030 (2429361) 2429361..2429573 - 213 WP_000087756.1 cold shock-like protein CspF -
N1709_RS12035 (2429874) 2429874..2430089 + 216 WP_000066484.1 cold shock-like protein CspB -
N1709_RS12040 (2430453) 2430453..2430623 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
N1709_RS12045 (2430843) 2430843..2431058 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2399423..2468716 69293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T257248 WP_000323025.1 NZ_CP104117:2425795-2426082 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT257248 WP_000534858.1 NZ_CP104117:2425556-2425795 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References