257242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1408032..1408657 Replicon chromosome
Accession NZ_CP104117
Organism Escherichia coli strain USDA-ARS-USMARC-50748

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N1709_RS06890 Protein ID WP_000911330.1
Coordinates 1408259..1408657 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag N1709_RS06885 Protein ID WP_000450524.1
Coordinates 1408032..1408259 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1709_RS06860 (1403835) 1403835..1404305 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
N1709_RS06865 (1404305) 1404305..1404877 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
N1709_RS06870 (1405023) 1405023..1405901 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
N1709_RS06875 (1405918) 1405918..1406952 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
N1709_RS06880 (1407165) 1407165..1407878 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
N1709_RS06885 (1408032) 1408032..1408259 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
N1709_RS06890 (1408259) 1408259..1408657 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
N1709_RS06895 (1408804) 1408804..1409667 + 864 WP_001267508.1 neutral zinc metallopeptidase -
N1709_RS06900 (1409682) 1409682..1411697 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
N1709_RS06905 (1411771) 1411771..1412469 + 699 WP_000679823.1 esterase -
N1709_RS06910 (1412579) 1412579..1412779 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T257242 WP_000911330.1 NZ_CP104117:1408259-1408657 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT257242 WP_000450524.1 NZ_CP104117:1408032-1408259 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References