257237

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 347246..347832 Replicon chromosome
Accession NZ_CP104117
Organism Escherichia coli strain USDA-ARS-USMARC-50748

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag N1709_RS01590 Protein ID WP_042014162.1
Coordinates 347246..347476 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N1709_RS01595 Protein ID WP_000593555.1
Coordinates 347473..347832 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1709_RS01580 (343283) 343283..346018 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
N1709_RS01585 (346018) 346018..347142 + 1125 WP_001314210.1 ABC transporter permease -
N1709_RS01590 (347246) 347246..347476 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
N1709_RS01595 (347473) 347473..347832 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N1709_RS01600 (347952) 347952..348353 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N1709_RS01605 (348359) 348359..349165 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
N1709_RS01610 (349162) 349162..349926 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
N1709_RS01615 (349926) 349926..350759 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N1709_RS01620 (350756) 350756..351700 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T257237 WP_042014162.1 NZ_CP104117:347246-347476 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT257237 WP_000593555.1 NZ_CP104117:347473-347832 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References