Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1043296..1043916 Replicon chromosome
Accession NC_016514
Organism Enterobacter cloacae EcWSU1

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag ECWSU1_RS04895 Protein ID WP_014168902.1
Coordinates 1043296..1043514 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag ECWSU1_RS04900 Protein ID WP_020885187.1
Coordinates 1043542..1043916 (-) Length 125 a.a.

Genomic Context

ECWSU1_RS04865ECWSU1_RS04870ECWSU1_RS04880ECWSU1_RS04875ECWSU1_RS04885ECWSU1_RS04890ECWSU1_RS04895ECWSU1_RS04900ECWSU1_RS04905ECWSU1_RS04910
Location: 1039307..1039567 (261 bp)
Type: Others
Protein ID: WP_010428154.1
Location: 1039570..1039710 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1040518..1041978 (1461 bp)
Type: Others
Protein ID: WP_014168898.1
Location: 1039707..1040417 (711 bp)
Type: Others
Protein ID: WP_014168897.1
Location: 1041950..1042417 (468 bp)
Type: Others
Protein ID: WP_020885189.1
Location: 1042535..1043086 (552 bp)
Type: Others
Protein ID: WP_020885188.1
Location: 1043296..1043514 (219 bp)
Type: Toxin
Protein ID: WP_014168902.1
Location: 1043542..1043916 (375 bp)
Type: Antitoxin
Protein ID: WP_020885187.1
Location: 1044428..1047574 (3147 bp)
Type: Others
Protein ID: WP_014168904.1
Location: 1047597..1048790 (1194 bp)
Type: Others
Protein ID: WP_032677536.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECWSU1_RS048651039307..1039567+261WP_010428154.1type B 50S ribosomal protein L31-
ECWSU1_RS048701039570..1039710+141WP_003859006.1type B 50S ribosomal protein L36-
ECWSU1_RS048751039707..1040417-711WP_014168897.1GNAT family N-acetyltransferase-
ECWSU1_RS048801040518..1041978+1461WP_014168898.1PLP-dependent aminotransferase family protein-
ECWSU1_RS048851041950..1042417-468WP_020885189.1extracytoplasmic function sigma factor YlaC-
ECWSU1_RS048901042535..1043086-552WP_020885188.1maltose O-acetyltransferase-
ECWSU1_RS048951043296..1043514-219WP_014168902.1hemolysin expression modulator HhaToxin
ECWSU1_RS049001043542..1043916-375WP_020885187.1Hha toxicity modulator TomBAntitoxin
ECWSU1_RS049051044428..1047574-3147WP_014168904.1multidrug efflux RND transporter permease subunit-
ECWSU1_RS049101047597..1048790-1194WP_032677536.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T25723 WP_014168902.1 NC_016514:c1043514-1043296 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T25723 NC_016514:c1043514-1043296 [Enterobacter ludwigii]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGTCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT25723 WP_020885187.1 NC_016514:c1043916-1043542 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT25723 NC_016514:c1043916-1043542 [Enterobacter ludwigii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A839BM33

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5C1BX74

References