Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2144593..2145231 Replicon chromosome
Accession NZ_CP104112
Organism Escherichia coli strain USDA-ARS-USMARC-51688

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N1707_RS10480 Protein ID WP_000813794.1
Coordinates 2144593..2144769 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N1707_RS10485 Protein ID WP_001270286.1
Coordinates 2144815..2145231 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1707_RS10460 (2140212) 2140212..2141426 - 1215 WP_001326689.1 BenE family transporter YdcO -
N1707_RS10465 (2141479) 2141479..2142015 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N1707_RS10470 (2142088) 2142088..2144049 + 1962 WP_167788885.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N1707_RS10475 (2144141) 2144141..2144371 - 231 WP_000494244.1 YncJ family protein -
N1707_RS10480 (2144593) 2144593..2144769 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N1707_RS10485 (2144815) 2144815..2145231 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N1707_RS10490 (2145310) 2145310..2146716 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N1707_RS10495 (2146961) 2146961..2148106 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N1707_RS10500 (2148124) 2148124..2149137 + 1014 WP_000220399.1 ABC transporter ATP-binding protein -
N1707_RS10505 (2149138) 2149138..2150079 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257204 WP_000813794.1 NZ_CP104112:2144593-2144769 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257204 WP_001270286.1 NZ_CP104112:2144815-2145231 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References