Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1565358..1566063 Replicon chromosome
Accession NZ_CP104112
Organism Escherichia coli strain USDA-ARS-USMARC-51688

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag N1707_RS07610 Protein ID WP_000539521.1
Coordinates 1565677..1566063 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N1707_RS07605 Protein ID WP_001280945.1
Coordinates 1565358..1565687 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1707_RS07595 (1561604) 1561604..1563952 + 2349 WP_001338403.1 EAL domain-containing protein -
N1707_RS07600 (1563960) 1563960..1565288 + 1329 WP_000086877.1 GGDEF domain-containing protein -
N1707_RS07605 (1565358) 1565358..1565687 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N1707_RS07610 (1565677) 1565677..1566063 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1707_RS07615 (1566289) 1566289..1567614 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N1707_RS07620 (1567827) 1567827..1568210 + 384 WP_000497137.1 biofilm formation regulator BssR -
N1707_RS07625 (1568321) 1568321..1569436 + 1116 WP_000555031.1 aldose sugar dehydrogenase YliI -
N1707_RS07630 (1569433) 1569433..1570059 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T257197 WP_000539521.1 NZ_CP104112:c1566063-1565677 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT257197 WP_001280945.1 NZ_CP104112:c1565687-1565358 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References