Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1145796..1146414 Replicon chromosome
Accession NZ_CP104112
Organism Escherichia coli strain USDA-ARS-USMARC-51688

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N1707_RS05575 Protein ID WP_001291435.1
Coordinates 1145796..1146014 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N1707_RS05580 Protein ID WP_000344800.1
Coordinates 1146040..1146414 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1707_RS05540 (1141085) 1141085..1141657 + 573 WP_000779831.1 YbaY family lipoprotein -
N1707_RS05545 (1141688) 1141688..1141999 - 312 WP_000409911.1 MGMT family protein -
N1707_RS05555 (1142378) 1142378..1142731 + 354 WP_000878140.1 DUF1428 domain-containing protein -
N1707_RS05560 (1142773) 1142773..1144323 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N1707_RS05565 (1144487) 1144487..1144957 - 471 WP_000136192.1 YlaC family protein -
N1707_RS05570 (1145073) 1145073..1145624 - 552 WP_000102564.1 maltose O-acetyltransferase -
N1707_RS05575 (1145796) 1145796..1146014 - 219 WP_001291435.1 HHA domain-containing protein Toxin
N1707_RS05580 (1146040) 1146040..1146414 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N1707_RS05585 (1146960) 1146960..1150109 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N1707_RS05590 (1150132) 1150132..1151325 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257196 WP_001291435.1 NZ_CP104112:c1146014-1145796 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257196 WP_000344800.1 NZ_CP104112:c1146414-1146040 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References