Detailed information of TA system TA257191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4967135..4968816
• Replicon: chromosome
• Accession: NZ_CP104110
• Organism: Klebsiella pneumoniae strain USDA-ARS-USMARC-52099

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: N1708_RS24180
• Protein ID: WP_004146663.1
• Coordinates: 4967135..4968052 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: N1708_RS24185
• Protein ID: WP_004177809.1
• Coordinates: 4968058..4968816 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N1708_RS24160 (4962441)	4962441..4963961	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
N1708_RS24165 (4963958)	4963958..4964956	+	999	WP_080899950.1	ribose ABC transporter permease	-
N1708_RS24170 (4964987)	4964987..4965928	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
N1708_RS24175 (4966003)	4966003..4967010	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
N1708_RS24180 (4967135)	4967135..4968052	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N1708_RS24185 (4968058)	4968058..4968816	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
N1708_RS24190 (4968902)	4968902..4969630	-	729	WP_023288135.1	response regulator transcription factor	-
N1708_RS24195 (4969903)	4969903..4972050	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
N1708_RS24200 (4972280)	4972280..4972966	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T257191 WP_004146663.1 NZ_CP104110:c4968052-4967135 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT257191 WP_004177809.1 NZ_CP104110:c4968816-4968058 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05