Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4808712..4809228 Replicon chromosome
Accession NZ_CP104110
Organism Klebsiella pneumoniae strain USDA-ARS-USMARC-52099

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag N1708_RS23365 Protein ID WP_009486548.1
Coordinates 4808712..4808996 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag N1708_RS23370 Protein ID WP_002886901.1
Coordinates 4808986..4809228 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1708_RS23340 (4804129) 4804129..4804437 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
N1708_RS23345 (4804522) 4804522..4804695 + 174 WP_002886906.1 hypothetical protein -
N1708_RS23350 (4804698) 4804698..4805441 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
N1708_RS23355 (4805798) 4805798..4807936 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
N1708_RS23360 (4808244) 4808244..4808708 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N1708_RS23365 (4808712) 4808712..4808996 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1708_RS23370 (4808986) 4808986..4809228 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N1708_RS23375 (4809306) 4809306..4811216 - 1911 WP_009486549.1 PRD domain-containing protein -
N1708_RS23380 (4811239) 4811239..4812393 - 1155 WP_020316350.1 lactonase family protein -
N1708_RS23385 (4812460) 4812460..4813200 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T257190 WP_009486548.1 NZ_CP104110:c4808996-4808712 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT257190 WP_002886901.1 NZ_CP104110:c4809228-4808986 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References