Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2672442..2674030 Replicon chromosome
Accession NZ_CP104110
Organism Klebsiella pneumoniae strain USDA-ARS-USMARC-52099

Toxin (Protein)


Gene name hipA Uniprot ID A0A486MZ73
Locus tag N1708_RS13005 Protein ID WP_009485244.1
Coordinates 2672442..2673764 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag N1708_RS13010 Protein ID WP_002904790.1
Coordinates 2673764..2674030 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1708_RS12990 (2667498) 2667498..2669999 + 2502 WP_009485242.1 fimbria/pilus outer membrane usher protein -
N1708_RS12995 (2669987) 2669987..2670991 + 1005 WP_009485243.1 fimbrial protein -
N1708_RS13000 (2671133) 2671133..2672425 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
N1708_RS13005 (2672442) 2672442..2673764 - 1323 WP_009485244.1 type II toxin-antitoxin system HipA family toxin Toxin
N1708_RS13010 (2673764) 2673764..2674030 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N1708_RS13015 (2674296) 2674296..2674622 - 327 WP_002904788.1 hydroxyisourate hydrolase -
N1708_RS13020 (2674619) 2674619..2675119 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N1708_RS13025 (2675097) 2675097..2676476 - 1380 WP_260197923.1 nucleobase:cation symporter-2 family protein -
N1708_RS13030 (2676822) 2676822..2677976 + 1155 WP_009485247.1 FAD-dependent urate hydroxylase HpxO -
N1708_RS13035 (2677957) 2677957..2678880 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2469740..2709513 239773


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49157.50 Da        Isoelectric Point: 7.5062

>T257186 WP_009485244.1 NZ_CP104110:c2673764-2672442 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT257186 WP_002904790.1 NZ_CP104110:c2674030-2673764 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486MZ73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References