Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870020..870677 Replicon chromosome
Accession NZ_CP104110
Organism Klebsiella pneumoniae strain USDA-ARS-USMARC-52099

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag N1708_RS04260 Protein ID WP_002916310.1
Coordinates 870267..870677 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N1708_RS04255 Protein ID WP_002916312.1
Coordinates 870020..870286 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1708_RS04230 (865176) 865176..866609 - 1434 WP_040219565.1 6-phospho-beta-glucosidase -
N1708_RS04235 (866728) 866728..867456 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N1708_RS04240 (867506) 867506..867817 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
N1708_RS04245 (867981) 867981..868640 + 660 WP_002916317.1 hemolysin III family protein -
N1708_RS04250 (868791) 868791..869774 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
N1708_RS04255 (870020) 870020..870286 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N1708_RS04260 (870267) 870267..870677 + 411 WP_002916310.1 protein YgfX Toxin
N1708_RS04265 (870684) 870684..871205 - 522 WP_004144730.1 flavodoxin FldB -
N1708_RS04270 (871306) 871306..872202 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N1708_RS04275 (872225) 872225..872938 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N1708_RS04280 (872944) 872944..874677 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T257181 WP_002916310.1 NZ_CP104110:870267-870677 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT257181 WP_002916312.1 NZ_CP104110:870020-870286 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References