Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 20861..22464 Replicon plasmid pCs1-54664
Accession NZ_CP104109
Organism Cronobacter sakazakii strain USDA-ARS-USMARC-54664

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N1710_RS20025 Protein ID WP_097641085.1
Coordinates 20861..22180 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N1710_RS20030 Protein ID WP_097650170.1
Coordinates 22183..22464 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1710_RS20015 (N1710_20015) 16243..18774 - 2532 WP_105568484.1 malto-oligosyltrehalose synthase -
N1710_RS20020 (N1710_20020) 18771..20555 - 1785 WP_038878178.1 malto-oligosyltrehalose trehalohydrolase -
N1710_RS20025 (N1710_20025) 20861..22180 - 1320 WP_097641085.1 type II toxin-antitoxin system HipA family toxin Toxin
N1710_RS20030 (N1710_20030) 22183..22464 - 282 WP_097650170.1 helix-turn-helix domain-containing protein Antitoxin
N1710_RS20035 (N1710_20035) 22595..23479 - 885 WP_097566364.1 siderophore-interacting protein -
N1710_RS20040 (N1710_20040) 23476..24687 - 1212 WP_069682124.1 MFS transporter -
N1710_RS20045 (N1710_20045) 24823..26571 + 1749 WP_105568485.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mgtB / iucA / iucB / iucC / iutA / pla / vipA/tssB / hcp/tssD / clpV/tssH 1..125991 125991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49083.07 Da        Isoelectric Point: 7.0032

>T257179 WP_097641085.1 NZ_CP104109:c22180-20861 [Cronobacter sakazakii]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEDQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVARTQMAQFEEQKVLIVERFDR
RLSGDGRWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRSGSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10501.99 Da        Isoelectric Point: 9.0637

>AT257179 WP_097650170.1 NZ_CP104109:c22464-22183 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAEADA
PARDDSPAHREAW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References