Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3096607..3097226 Replicon chromosome
Accession NZ_CP104108
Organism Cronobacter sakazakii strain USDA-ARS-USMARC-54664

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag N1710_RS14670 Protein ID WP_004386909.1
Coordinates 3097008..3097226 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag N1710_RS14665 Protein ID WP_004386908.1
Coordinates 3096607..3096981 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1710_RS14655 (N1710_14655) 3091768..3092973 + 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N1710_RS14660 (N1710_14660) 3092995..3096144 + 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
N1710_RS14665 (N1710_14665) 3096607..3096981 + 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
N1710_RS14670 (N1710_14670) 3097008..3097226 + 219 WP_004386909.1 HHA domain-containing protein Toxin
N1710_RS14675 (N1710_14675) 3097433..3097984 + 552 WP_004386910.1 maltose O-acetyltransferase -
N1710_RS14680 (N1710_14680) 3098104..3098613 + 510 WP_105545632.1 YlaC family protein -
N1710_RS14685 (N1710_14685) 3098642..3098782 - 141 WP_004386911.1 type B 50S ribosomal protein L36 -
N1710_RS14690 (N1710_14690) 3098786..3099046 - 261 WP_105546096.1 type B 50S ribosomal protein L31 -
N1710_RS14695 (N1710_14695) 3099186..3101087 - 1902 WP_014729414.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T257177 WP_004386909.1 NZ_CP104108:3097008-3097226 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT257177 WP_004386908.1 NZ_CP104108:3096607-3096981 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References