Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 2993..3594 Replicon plasmid pPF
Accession NZ_CP104090
Organism Lactiplantibacillus plantarum strain VHProbi P06

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NYQ69_RS16450 Protein ID WP_265049708.1
Coordinates 3250..3594 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A806J926
Locus tag NYQ69_RS16445 Protein ID WP_001748109.1
Coordinates 2993..3256 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ69_RS16440 (NYQ69_16440) 2320..2907 - 588 WP_041153703.1 site-specific integrase -
NYQ69_RS16445 (NYQ69_16445) 2993..3256 + 264 WP_001748109.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NYQ69_RS16450 (NYQ69_16450) 3250..3594 + 345 WP_265049708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYQ69_RS16455 (NYQ69_16455) 3713..5044 - 1332 WP_265049709.1 NAD(P)/FAD-dependent oxidoreductase -
NYQ69_RS16460 (NYQ69_16460) 5062..5193 - 132 WP_015474697.1 hypothetical protein -
NYQ69_RS16465 (NYQ69_16465) 5206..5853 - 648 WP_006844821.1 DsbA family oxidoreductase -
NYQ69_RS16470 (NYQ69_16470) 5872..6816 - 945 WP_006844822.1 thioredoxin-disulfide reductase -
NYQ69_RS16475 (NYQ69_16475) 6907..7035 - 129 Protein_8 aspartate racemase -
NYQ69_RS16480 (NYQ69_16480) 7035..7358 - 324 WP_265049707.1 thioredoxin family protein -
NYQ69_RS16485 (NYQ69_16485) 7379..7693 - 315 WP_015474701.1 thioredoxin -
NYQ69_RS16490 (NYQ69_16490) 7707..7988 - 282 WP_008855846.1 thioredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14030 14030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-101)

Antitoxin

Antitoxin PemI-like

(8-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12993.90 Da        Isoelectric Point: 6.4748

>T257149 WP_265049708.1 NZ_CP104090:3250-3594 [Lactiplantibacillus plantarum]
MVSQGDIFYVNFNPSRGHEQMNKRPAIALSNDLVCQTSNMTIVAPISSTKRNFPMYHRLISSQTVCGKVLLDQTIALDLR
ARHVTDETIVDHVSREELEEIITLYKLLFSIDDK

Download         Length: 345 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10141.47 Da        Isoelectric Point: 5.7117

>AT257149 WP_001748109.1 NZ_CP104090:2993-3256 [Lactiplantibacillus plantarum]
MELIKEQTRLAKWGNSKAARIPSQIIKQLKLDDNQDMTITIENGSIVLTPIKKNPTNIHELFKDWQDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806J926

References