Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 18435..19078 Replicon plasmid pHB42-3
Accession NZ_CP104080
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag N0M81_RS24025 Protein ID WP_001044768.1
Coordinates 18435..18851 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag N0M81_RS24030 Protein ID WP_001261287.1
Coordinates 18848..19078 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS24010 (N0M81_24010) 14934..15524 - 591 WP_000194575.1 hypothetical protein -
N0M81_RS24015 (N0M81_24015) 15524..15781 - 258 WP_000343085.1 hypothetical protein -
N0M81_RS24020 (N0M81_24020) 16135..18273 + 2139 WP_000350638.1 AAA family ATPase -
N0M81_RS24025 (N0M81_24025) 18435..18851 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
N0M81_RS24030 (N0M81_24030) 18848..19078 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
N0M81_RS24035 (N0M81_24035) 19374..19664 + 291 WP_000111771.1 hypothetical protein -
N0M81_RS24040 (N0M81_24040) 19654..20553 + 900 WP_000963206.1 nucleotide-binding protein -
N0M81_RS24045 (N0M81_24045) 20603..22594 - 1992 WP_259904992.1 KAP family NTPase -
N0M81_RS24050 (N0M81_24050) 22548..22829 - 282 WP_259904994.1 KAP family NTPase -
N0M81_RS24055 (N0M81_24055) 22831..23919 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR - 1..61731 61731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T257145 WP_001044768.1 NZ_CP104080:c18851-18435 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT257145 WP_001261287.1 NZ_CP104080:c19078-18848 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References