Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 3388..3910 Replicon plasmid pHB42-3
Accession NZ_CP104080
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag N0M81_RS23940 Protein ID WP_000220561.1
Coordinates 3629..3910 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag N0M81_RS23935 Protein ID WP_000121743.1
Coordinates 3388..3639 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS23920 (N0M81_23920) 1..447 - 447 WP_001074384.1 hypothetical protein -
N0M81_RS23925 (N0M81_23925) 451..1293 - 843 WP_000435064.1 replication initiation protein -
N0M81_RS23930 (N0M81_23930) 1314..2153 - 840 WP_024129959.1 replication initiation protein -
N0M81_RS23935 (N0M81_23935) 3388..3639 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
N0M81_RS23940 (N0M81_23940) 3629..3910 + 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0M81_RS23945 (N0M81_23945) 4149..4241 - 93 Protein_5 IS6 family transposase -
N0M81_RS23950 (N0M81_23950) 4407..5606 - 1200 WP_000948429.1 IS91 family transposase -
N0M81_RS23955 (N0M81_23955) 5616..5804 - 189 WP_000957857.1 hypothetical protein -
N0M81_RS23960 (N0M81_23960) 5924..7354 + 1431 Protein_8 IS4-like element IS50R family transposase -
N0M81_RS23965 (N0M81_23965) 7383..8177 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -
N0M81_RS23970 (N0M81_23970) 8198..8434 + 237 Protein_10 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(3')-IIa / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR - 1..61731 61731


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T257144 WP_000220561.1 NZ_CP104080:3629-3910 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT257144 WP_000121743.1 NZ_CP104080:3388-3639 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References