Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 144878..145503 Replicon plasmid pHB42-1
Accession NZ_CP104078
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag N0M81_RS23295 Protein ID WP_000911313.1
Coordinates 144878..145276 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag N0M81_RS23300 Protein ID WP_000450520.1
Coordinates 145276..145503 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS23280 (141203) 141203..141700 + 498 WP_000605857.1 entry exclusion protein -
N0M81_RS23285 (141732) 141732..142463 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
N0M81_RS23290 (142716) 142716..144869 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
N0M81_RS23295 (144878) 144878..145276 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
N0M81_RS23300 (145276) 145276..145503 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aac(3)-IId / mph(A) / fosA3 / blaCTX-M-14 / sitABCD iroN / iroE / iroD / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..154403 154403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T257140 WP_000911313.1 NZ_CP104078:c145276-144878 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT257140 WP_000450520.1 NZ_CP104078:c145503-145276 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References