Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4074899..4075494 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag N0M81_RS19480 Protein ID WP_000239581.1
Coordinates 4074899..4075249 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag N0M81_RS19485 Protein ID WP_001223213.1
Coordinates 4075243..4075494 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS19460 (4070353) 4070353..4071375 - 1023 WP_001361374.1 ABC transporter permease -
N0M81_RS19465 (4071389) 4071389..4072891 - 1503 WP_001095661.1 ATP-binding cassette domain-containing protein -
N0M81_RS19470 (4073024) 4073024..4073980 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N0M81_RS19475 (4074290) 4074290..4074820 + 531 WP_000055072.1 inorganic diphosphatase -
N0M81_RS19480 (4074899) 4074899..4075249 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
N0M81_RS19485 (4075243) 4075243..4075494 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N0M81_RS19490 (4075706) 4075706..4076047 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N0M81_RS19495 (4076050) 4076050..4079829 - 3780 WP_000060873.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T257132 WP_000239581.1 NZ_CP104077:c4075249-4074899 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT257132 WP_001223213.1 NZ_CP104077:c4075494-4075243 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References