Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4063555..4064077 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag N0M81_RS19420 Protein ID WP_001105432.1
Coordinates 4063555..4063845 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag N0M81_RS19425 Protein ID WP_000212715.1
Coordinates 4063835..4064077 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS19405 (4058718) 4058718..4060373 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
N0M81_RS19410 (4060767) 4060767..4062905 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
N0M81_RS19415 (4063090) 4063090..4063554 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N0M81_RS19420 (4063555) 4063555..4063845 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0M81_RS19425 (4063835) 4063835..4064077 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N0M81_RS19430 (4064269) 4064269..4064655 - 387 WP_001232253.1 cytochrome b562 -
N0M81_RS19435 (4064711) 4064711..4066063 - 1353 WP_001162172.1 metalloprotease PmbA -
N0M81_RS19440 (4066157) 4066157..4066708 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
N0M81_RS19445 (4066791) 4066791..4068164 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T257131 WP_001105432.1 NZ_CP104077:c4063845-4063555 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT257131 WP_000212715.1 NZ_CP104077:c4064077-4063835 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References