Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3437491..3438109 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N0M81_RS16430 Protein ID WP_001291435.1
Coordinates 3437891..3438109 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N0M81_RS16425 Protein ID WP_000344800.1
Coordinates 3437491..3437865 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS16415 (3432580) 3432580..3433773 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N0M81_RS16420 (3433796) 3433796..3436945 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
N0M81_RS16425 (3437491) 3437491..3437865 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N0M81_RS16430 (3437891) 3437891..3438109 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N0M81_RS16435 (3438281) 3438281..3438832 + 552 WP_000102574.1 maltose O-acetyltransferase -
N0M81_RS16440 (3438948) 3438948..3439418 + 471 WP_000136192.1 YlaC family protein -
N0M81_RS16445 (3439582) 3439582..3441132 + 1551 WP_001361689.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N0M81_RS16450 (3441174) 3441174..3441527 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N0M81_RS16460 (3441906) 3441906..3442217 + 312 WP_000409911.1 MGMT family protein -
N0M81_RS16465 (3442248) 3442248..3442820 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T257128 WP_001291435.1 NZ_CP104077:3437891-3438109 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT257128 WP_000344800.1 NZ_CP104077:3437491-3437865 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References