Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3059896..3060601 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name relE Uniprot ID A0A1M2J6W7
Locus tag N0M81_RS14625 Protein ID WP_000539524.1
Coordinates 3059896..3060282 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N0M81_RS14630 Protein ID WP_001280945.1
Coordinates 3060272..3060601 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS14605 (3055900) 3055900..3056526 + 627 WP_001295292.1 glutathione S-transferase GstB -
N0M81_RS14610 (3056523) 3056523..3057638 - 1116 WP_000555056.1 aldose sugar dehydrogenase YliI -
N0M81_RS14615 (3057749) 3057749..3058132 - 384 WP_000497137.1 biofilm formation regulator BssR -
N0M81_RS14620 (3058345) 3058345..3059670 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N0M81_RS14625 (3059896) 3059896..3060282 + 387 WP_000539524.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0M81_RS14630 (3060272) 3060272..3060601 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N0M81_RS14635 (3060671) 3060671..3061988 - 1318 Protein_2870 diguanylate cyclase -
N0M81_RS14640 (3061996) 3061996..3064344 - 2349 WP_000950331.1 EAL domain-containing protein -
N0M81_RS14645 (3064521) 3064521..3065432 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14321.46 Da        Isoelectric Point: 9.9521

>T257126 WP_000539524.1 NZ_CP104077:3059896-3060282 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT257126 WP_001280945.1 NZ_CP104077:3060272-3060601 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M2J6W7

Antitoxin

Source ID Structure

References