Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1902829..1903613 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag N0M81_RS08940 Protein ID WP_000613626.1
Coordinates 1902829..1903323 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag N0M81_RS08945 Protein ID WP_001110447.1
Coordinates 1903320..1903613 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS08920 (1898022) 1898022..1899119 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
N0M81_RS08925 (1899119) 1899119..1900060 + 942 WP_001305885.1 flagellar assembly peptidoglycan hydrolase FlgJ -
N0M81_RS08930 (1900126) 1900126..1901769 + 1644 WP_061092652.1 flagellar hook-associated protein FlgK -
N0M81_RS08935 (1901781) 1901781..1902734 + 954 WP_001212762.1 flagellar hook-associated protein FlgL -
N0M81_RS08940 (1902829) 1902829..1903323 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
N0M81_RS08945 (1903320) 1903320..1903613 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
N0M81_RS08950 (1903746) 1903746..1906931 - 3186 WP_061092653.1 ribonuclease E -
N0M81_RS08955 (1907504) 1907504..1908463 + 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T257120 WP_000613626.1 NZ_CP104077:c1903323-1902829 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT257120 WP_001110447.1 NZ_CP104077:c1903613-1903320 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References