Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 892642..893296 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N0M81_RS04360 Protein ID WP_000244781.1
Coordinates 892889..893296 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N0M81_RS04355 Protein ID WP_000354046.1
Coordinates 892642..892908 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS04335 (888730) 888730..890163 - 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -
N0M81_RS04340 (890208) 890208..890519 + 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
N0M81_RS04345 (890683) 890683..891342 + 660 WP_259904223.1 hemolysin III family protein -
N0M81_RS04350 (891419) 891419..892399 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
N0M81_RS04355 (892642) 892642..892908 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N0M81_RS04360 (892889) 892889..893296 + 408 WP_000244781.1 protein YgfX Toxin
N0M81_RS04365 (893336) 893336..893857 - 522 WP_001521233.1 flavodoxin FldB -
N0M81_RS04370 (893969) 893969..894865 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N0M81_RS04375 (894890) 894890..895600 + 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N0M81_RS04380 (895606) 895606..897339 + 1734 WP_063117505.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T257118 WP_000244781.1 NZ_CP104077:892889-893296 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT257118 WP_000354046.1 NZ_CP104077:892642-892908 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References