Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 351288..351919 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag N0M81_RS01600 Protein ID WP_001260301.1
Coordinates 351288..351563 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N0M81_RS01605 Protein ID WP_000593555.1
Coordinates 351560..351919 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS01585 (346292) 346292..347359 + 1068 WP_000361497.1 HlyD family efflux transporter periplasmic adaptor subunit -
N0M81_RS01590 (347356) 347356..350091 + 2736 WP_061092822.1 ribosome-associated ATPase/putative transporter RbbA -
N0M81_RS01595 (350091) 350091..351215 + 1125 WP_001314210.1 ABC transporter permease -
N0M81_RS01600 (351288) 351288..351563 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
N0M81_RS01605 (351560) 351560..351919 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0M81_RS01610 (352039) 352039..352440 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
N0M81_RS01615 (352445) 352445..353251 - 807 WP_061092823.1 nickel import ATP-binding protein NikE -
N0M81_RS01620 (353248) 353248..354012 - 765 WP_001136211.1 nickel import ATP-binding protein NikD -
N0M81_RS01625 (354012) 354012..354845 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
N0M81_RS01630 (354842) 354842..355786 - 945 WP_000947080.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 344304..352440 8136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T257115 WP_001260301.1 NZ_CP104077:351288-351563 [Escherichia coli]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT257115 WP_000593555.1 NZ_CP104077:351560-351919 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References