Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 211161..211773 Replicon chromosome
Accession NZ_CP104077
Organism Escherichia coli strain HB42

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag N0M81_RS00990 Protein ID WP_000833473.1
Coordinates 211161..211346 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M2IVK0
Locus tag N0M81_RS00995 Protein ID WP_000499742.1
Coordinates 211363..211773 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0M81_RS00975 (206627) 206627..207922 + 1296 WP_000985745.1 Fic family protein -
N0M81_RS00980 (208030) 208030..209568 + 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
N0M81_RS00985 (209609) 209609..210688 - 1080 WP_000061475.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
N0M81_RS00990 (211161) 211161..211346 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
N0M81_RS00995 (211363) 211363..211773 + 411 WP_000499742.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0M81_RS01000 (211885) 211885..213864 - 1980 WP_001026863.1 glycoside hydrolase family 127 protein -
N0M81_RS01005 (213875) 213875..215275 - 1401 WP_000204814.1 MFS transporter -
N0M81_RS01010 (215501) 215501..216316 + 816 WP_000891820.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T257114 WP_000833473.1 NZ_CP104077:211161-211346 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15242.13 Da        Isoelectric Point: 4.4482

>AT257114 WP_000499742.1 NZ_CP104077:211363-211773 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMDEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2IVK0

References