Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 265657..266305 Replicon chromosome
Accession NZ_CP104071
Organism Stenotrophomonas maltophilia strain ACYCb.6H

Toxin (Protein)


Gene name PumA Uniprot ID A0A0L8AET4
Locus tag K7565_RS01175 Protein ID WP_010486984.1
Coordinates 265657..265944 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A0U5HHQ5
Locus tag K7565_RS01180 Protein ID WP_058979789.1
Coordinates 266003..266305 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7565_RS01145 (K7565_01145) 261600..262391 - 792 WP_227844239.1 zinc-dependent peptidase -
K7565_RS01150 (K7565_01150) 262358..262636 - 279 WP_005411956.1 hypothetical protein -
K7565_RS01155 (K7565_01155) 262781..263749 + 969 WP_019661841.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
K7565_RS01160 (K7565_01160) 263746..264477 + 732 WP_019661840.1 type III pantothenate kinase -
K7565_RS01165 (K7565_01165) 264487..265335 + 849 WP_227844240.1 SPOR domain-containing protein -
K7565_RS01175 (K7565_01175) 265657..265944 + 288 WP_010486984.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7565_RS01180 (K7565_01180) 266003..266305 + 303 WP_058979789.1 putative addiction module antidote protein Antitoxin
K7565_RS01185 (K7565_01185) 266474..266875 - 402 WP_155028816.1 hypothetical protein -
K7565_RS01190 (K7565_01190) 267458..268228 + 771 WP_227844241.1 DUF3011 domain-containing protein -
K7565_RS01195 (K7565_01195) 268253..268600 - 348 WP_057503835.1 hypothetical protein -
K7565_RS01200 (K7565_01200) 268732..269652 + 921 WP_111097684.1 arginase -
K7565_RS01205 (K7565_01205) 269815..269952 + 138 WP_019661832.1 entericidin A/B family lipoprotein -
K7565_RS01210 (K7565_01210) 270154..270375 + 222 WP_019661831.1 CsbD family protein -
K7565_RS01215 (K7565_01215) 270446..271246 - 801 WP_227844242.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.34 Da        Isoelectric Point: 10.8940

>T257112 WP_010486984.1 NZ_CP104071:265657-265944 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10694.26 Da        Isoelectric Point: 8.0343

>AT257112 WP_058979789.1 NZ_CP104071:266003-266305 [Stenotrophomonas maltophilia]
MATKKKVELKAFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L8AET4

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5HHQ5

References