Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 5392971..5393580 Replicon chromosome
Accession NZ_CP104067
Organism Alicyclobacillus fastidiosus strain DSM 17978

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NZD89_RS26245 Protein ID WP_268005580.1
Coordinates 5392971..5393321 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NZD89_RS26250 Protein ID WP_268008623.1
Coordinates 5393326..5393580 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD89_RS26215 (NZD89_26225) 5388665..5389288 + 624 WP_268005574.1 DedA family protein -
NZD89_RS26220 (NZD89_26230) 5389661..5389879 - 219 WP_268005575.1 DUF2922 domain-containing protein -
NZD89_RS26225 (NZD89_26235) 5389926..5390165 - 240 WP_268005576.1 DUF1659 domain-containing protein -
NZD89_RS26230 (NZD89_26240) 5390412..5390717 + 306 WP_268005577.1 hypothetical protein -
NZD89_RS26235 (NZD89_26245) 5390862..5391596 - 735 WP_268005578.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NZD89_RS26240 (NZD89_26250) 5391613..5392866 - 1254 WP_268005579.1 adenosylhomocysteinase -
NZD89_RS26245 (NZD89_26255) 5392971..5393321 - 351 WP_268005580.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NZD89_RS26250 (NZD89_26260) 5393326..5393580 - 255 WP_268008623.1 ribbon-helix-helix protein, CopG family Antitoxin
NZD89_RS26255 (NZD89_26265) 5393680..5394909 - 1230 WP_268005581.1 alanine racemase -
NZD89_RS26260 (NZD89_26270) 5395086..5396084 - 999 WP_268008624.1 outer membrane lipoprotein carrier protein LolA -
NZD89_RS26265 (NZD89_26275) 5396126..5397610 - 1485 WP_268005582.1 NAD(P)H-hydrate dehydratase -
NZD89_RS26270 (NZD89_26280) 5397703..5398080 - 378 WP_268005583.1 holo-ACP synthase -
NZD89_RS26275 (NZD89_26285) 5398214..5398402 + 189 WP_268005584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12843.95 Da        Isoelectric Point: 5.6766

>T257110 WP_268005580.1 NZ_CP104067:c5393321-5392971 [Alicyclobacillus fastidiosus]
MNVKRGDVFFADLSPVVGSEQGGFRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIPAQPYGLERDSVVLLEQL
RTLDKQRLTDKITHLDDTMMKMVNDGLLISLGLVDF

Download         Length: 351 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9597.88 Da        Isoelectric Point: 4.8090

>AT257110 WP_268008623.1 NZ_CP104067:c5393580-5393326 [Alicyclobacillus fastidiosus]
MVVYVPEQLLEQVDGFARTDSANRSEIVREALRMYVTAHRKNDIREQMQQGYLEMARLNLRIASESFPLEQEAGGTVERL
VSGV

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References