257109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4243336..4243963 Replicon chromosome
Accession NZ_CP104064
Organism Alicyclobacillus dauci strain DSM 28700

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NZD86_RS21280 Protein ID WP_268044047.1
Coordinates 4243336..4243686 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NZD86_RS21285 Protein ID WP_268044048.1
Coordinates 4243691..4243963 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD86_RS21260 (NZD86_21280) 4238449..4240224 - 1776 WP_268044043.1 PAS domain-containing protein -
NZD86_RS21265 (NZD86_21285) 4240426..4240590 - 165 WP_268044044.1 hypothetical protein -
NZD86_RS21270 (NZD86_21290) 4241118..4241858 - 741 WP_268044045.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NZD86_RS21275 (NZD86_21295) 4241890..4243143 - 1254 WP_268044046.1 adenosylhomocysteinase -
NZD86_RS21280 (NZD86_21300) 4243336..4243686 - 351 WP_268044047.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NZD86_RS21285 (NZD86_21305) 4243691..4243963 - 273 WP_268044048.1 ribbon-helix-helix protein, CopG family Antitoxin
NZD86_RS21290 (NZD86_21310) 4244042..4245247 - 1206 WP_268044050.1 alanine racemase -
NZD86_RS21295 (NZD86_21315) 4245652..4246650 - 999 WP_268046994.1 outer membrane lipoprotein carrier protein LolA -
NZD86_RS21300 (NZD86_21320) 4246691..4248166 - 1476 WP_268044051.1 NAD(P)H-hydrate dehydratase -
NZD86_RS21305 (NZD86_21325) 4248265..4248642 - 378 WP_268044052.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-42)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12949.10 Da        Isoelectric Point: 6.4667

>T257109 WP_268044047.1 NZ_CP104064:c4243686-4243336 [Alicyclobacillus dauci]
MNVKRGDIFFADLSPVVGSEQGGFRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIPAQRYGLERDSVVLLEQL
RTLDKQRLTDKITHLDETMMKMVNDGLMISLGLVDF

Download         Length: 351 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10127.65 Da        Isoelectric Point: 8.6015

>AT257109 WP_268044048.1 NZ_CP104064:c4243963-4243691 [Alicyclobacillus dauci]
VSGKKRMIVNVPEQLLEQVDGVARTGSTNRSQIVREALRMYVSTHLKTEIREQMQQGYLEMARLNLRIASELFPLEQEAG
GTVDRLVSGV

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References