257108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4648909..4649552 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag NXZ70_RS22655 Protein ID WP_000048134.1
Coordinates 4648909..4649325 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag NXZ70_RS22660 Protein ID WP_001261294.1
Coordinates 4649322..4649552 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS22635 (4643946) 4643946..4645079 + 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -
NXZ70_RS22640 (4645063) 4645063..4646181 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NXZ70_RS22645 (4646178) 4646178..4646918 + 741 WP_000779255.1 KDGP aldolase family protein -
NXZ70_RS22650 (4646935) 4646935..4648848 + 1914 WP_001212148.1 BglG family transcription antiterminator -
NXZ70_RS22655 (4648909) 4648909..4649325 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
NXZ70_RS22660 (4649322) 4649322..4649552 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NXZ70_RS22665 (4649720) 4649720..4650184 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NXZ70_RS22670 (4650401) 4650401..4652539 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T257108 WP_000048134.1 NZ_CP104049:c4649325-4648909 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT257108 WP_001261294.1 NZ_CP104049:c4649552-4649322 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References