Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4510697..4511478 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NXZ70_RS21930 Protein ID WP_000625911.1
Coordinates 4510987..4511478 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NXZ70_RS21925 Protein ID WP_001271379.1
Coordinates 4510697..4510990 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS21890 (4506997) 4506997..4507902 + 906 WP_001268192.1 YjiK family protein -
NXZ70_RS21895 (4508197) 4508197..4508391 - 195 WP_223163373.1 hypothetical protein -
NXZ70_RS21900 (4508439) 4508439..4508538 - 100 Protein_4265 hypothetical protein -
NXZ70_RS21905 (4508558) 4508558..4508740 + 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
NXZ70_RS21910 (4508733) 4508733..4509020 - 288 WP_072103482.1 transcriptional regulator RtsB -
NXZ70_RS21915 (4509017) 4509017..4509892 - 876 WP_023205266.1 AraC family transcriptional regulator -
NXZ70_RS21920 (4510158) 4510158..4510379 - 222 WP_052939504.1 hypothetical protein -
NXZ70_RS21925 (4510697) 4510697..4510990 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NXZ70_RS21930 (4510987) 4510987..4511478 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NXZ70_RS21935 (4511693) 4511693..4511941 + 249 Protein_4272 IS481 family transposase -
NXZ70_RS21940 (4512216) 4512216..4512443 - 228 WP_001112992.1 hypothetical protein -
NXZ70_RS21945 (4513036) 4513036..4513320 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NXZ70_RS21950 (4513355) 4513355..4513894 + 540 WP_000721295.1 type 1 fimbrial protein -
NXZ70_RS21955 (4513904) 4513904..4516342 + 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 4508733..4524500 15767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T257107 WP_000625911.1 NZ_CP104049:4510987-4511478 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT257107 WP_001271379.1 NZ_CP104049:4510697-4510990 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References