Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3994453..3996076 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NXZ70_RS19515 Protein ID WP_000088046.1
Coordinates 3994751..3996076 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NXZ70_RS19510 Protein ID WP_024136327.1
Coordinates 3994453..3994746 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS19480 (3989873) 3989873..3990154 - 282 WP_000710431.1 hypothetical protein -
NXZ70_RS19485 (3990220) 3990220..3990675 - 456 WP_224435199.1 hypothetical protein -
NXZ70_RS19490 (3990741) 3990741..3991913 + 1173 WP_000952349.1 IS21-like element IS21 family transposase -
NXZ70_RS19495 (3991913) 3991913..3992710 + 798 WP_000544828.1 IS21-like element IS21 family helper ATPase IstB -
NXZ70_RS19500 (3992749) 3992749..3993084 - 336 WP_065311125.1 hypothetical protein -
NXZ70_RS19505 (3993457) 3993457..3993849 + 393 WP_000341066.1 hypothetical protein -
NXZ70_RS19510 (3994453) 3994453..3994746 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NXZ70_RS19515 (3994751) 3994751..3996076 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NXZ70_RS19520 (3996137) 3996137..3996343 + 207 WP_000134171.1 hypothetical protein -
NXZ70_RS19525 (3996445) 3996445..3996855 + 411 WP_000985911.1 hypothetical protein -
NXZ70_RS19530 (3996868) 3996868..3997683 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
NXZ70_RS19535 (3997937) 3997937..3998146 + 210 WP_223533973.1 hypothetical protein -
NXZ70_RS19540 (3998606) 3998606..3998953 + 348 WP_000609174.1 IS66 family insertion sequence element accessory protein TnpB -
NXZ70_RS19545 (3999003) 3999003..4000538 + 1536 WP_001000406.1 IS66 family transposase -
NXZ70_RS19550 (4000634) 4000634..4000807 + 174 WP_224435200.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3')-Ia - 3982705..4005304 22599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T257104 WP_000088046.1 NZ_CP104049:3994751-3996076 [Salmonella enterica subsp. enterica serovar Kentucky]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT257104 WP_024136327.1 NZ_CP104049:3994453-3994746 [Salmonella enterica subsp. enterica serovar Kentucky]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References