257102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3326163..3326977 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag NXZ70_RS16165 Protein ID WP_000971653.1
Coordinates 3326450..3326977 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NXZ70_RS16160 Protein ID WP_000855694.1
Coordinates 3326163..3326453 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS16130 (3322088) 3322088..3322738 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
NXZ70_RS16135 (3323196) 3323196..3323639 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NXZ70_RS16140 (3324071) 3324071..3324520 + 450 WP_023225038.1 hypothetical protein -
NXZ70_RS16145 (3324505) 3324505..3324852 + 348 WP_001555786.1 DUF1493 family protein -
NXZ70_RS16150 (3325125) 3325125..3325451 - 327 WP_000393295.1 hypothetical protein -
NXZ70_RS16155 (3325692) 3325692..3325892 + 201 Protein_3159 transposase -
NXZ70_RS16160 (3326163) 3326163..3326453 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NXZ70_RS16165 (3326450) 3326450..3326977 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
NXZ70_RS16170 (3327050) 3327050..3327252 - 203 Protein_3162 IS5/IS1182 family transposase -
NXZ70_RS16175 (3327602) 3327602..3328258 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
NXZ70_RS16180 (3328430) 3328430..3328924 - 495 WP_000424946.1 hypothetical protein -
NXZ70_RS16185 (3328951) 3328951..3329619 - 669 WP_000445914.1 hypothetical protein -
NXZ70_RS16190 (3329776) 3329776..3329994 - 219 Protein_3166 hypothetical protein -
NXZ70_RS16195 (3330205) 3330205..3330603 - 399 Protein_3167 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3325692..3327226 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T257102 WP_000971653.1 NZ_CP104049:3326450-3326977 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT257102 WP_000855694.1 NZ_CP104049:3326163-3326453 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References