257097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1968968..1969490 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NXZ70_RS09625 Protein ID WP_000221345.1
Coordinates 1968968..1969252 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NXZ70_RS09630 Protein ID WP_000885424.1
Coordinates 1969242..1969490 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS09605 (1965043) 1965043..1966551 - 1509 WP_023223898.1 FAD-dependent oxidoreductase -
NXZ70_RS09610 (1966596) 1966596..1967084 + 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
NXZ70_RS09615 (1967277) 1967277..1968356 + 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NXZ70_RS09620 (1968408) 1968408..1968797 - 390 WP_000194089.1 RidA family protein -
NXZ70_RS09625 (1968968) 1968968..1969252 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NXZ70_RS09630 (1969242) 1969242..1969490 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NXZ70_RS09635 (1969642) 1969642..1969761 + 120 Protein_1886 type II and III secretion system -
NXZ70_RS09640 (1969847) 1969847..1970178 + 332 Protein_1887 DUF1493 family protein -
NXZ70_RS09645 (1970451) 1970451..1971359 + 909 WP_077906523.1 hypothetical protein -
NXZ70_RS09650 (1971361) 1971361..1972100 - 740 Protein_1889 hypothetical protein -
NXZ70_RS09655 (1972466) 1972466..1972654 - 189 WP_001276021.1 DUF29 family protein -
NXZ70_RS09660 (1973056) 1973056..1973784 + 729 WP_240856007.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1967277..1978971 11694


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T257097 WP_000221345.1 NZ_CP104049:c1969252-1968968 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT257097 WP_000885424.1 NZ_CP104049:c1969490-1969242 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References