Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 195084..195844 | Replicon | chromosome |
| Accession | NZ_CP104049 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A5H3Y7E3 |
| Locus tag | NXZ70_RS00925 | Protein ID | WP_023225088.1 |
| Coordinates | 195359..195844 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | A0A3Z2K6C6 |
| Locus tag | NXZ70_RS00920 | Protein ID | WP_072106018.1 |
| Coordinates | 195084..195371 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NXZ70_RS00905 (191512) | 191512..191940 | + | 429 | Protein_179 | IS3 family transposase | - |
| NXZ70_RS00910 (192136) | 192136..192906 | - | 771 | WP_000456879.1 | DUF3800 domain-containing protein | - |
| NXZ70_RS00915 (193933) | 193933..194961 | + | 1029 | WP_023196719.1 | HNH endonuclease signature motif containing protein | - |
| NXZ70_RS00920 (195084) | 195084..195371 | + | 288 | WP_072106018.1 | DUF1778 domain-containing protein | Antitoxin |
| NXZ70_RS00925 (195359) | 195359..195844 | + | 486 | WP_023225088.1 | GNAT family N-acetyltransferase | Toxin |
| NXZ70_RS00930 (196214) | 196214..196753 | - | 540 | WP_000047141.1 | copper-binding periplasmic metallochaperone CueP | - |
| NXZ70_RS00935 (196926) | 196926..197138 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NXZ70_RS00940 (197426) | 197426..197716 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NXZ70_RS00945 (198155) | 198155..198865 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NXZ70_RS00950 (198915) | 198915..199889 | - | 975 | WP_023225087.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NXZ70_RS00955 (200108) | 200108..200770 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17756.43 Da Isoelectric Point: 9.0965
>T257092 WP_023225088.1 NZ_CP104049:195359-195844 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10982.66 Da Isoelectric Point: 4.6811
>AT257092 WP_072106018.1 NZ_CP104049:195084-195371 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H3Y7E3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z2K6C6 |