Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4982870..4983459 Replicon chromosome
Accession NZ_CP104044
Organism Pseudomonas sp. SD17-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N0B28_RS22705 Protein ID WP_078481358.1
Coordinates 4983211..4983459 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0D1P013
Locus tag N0B28_RS22700 Protein ID WP_043863853.1
Coordinates 4982870..4983211 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0B28_RS22685 (N0B28_22700) 4978253..4979308 + 1056 WP_043863850.1 membrane protein -
N0B28_RS22690 (N0B28_22705) 4979427..4980206 + 780 WP_100634089.1 class I SAM-dependent methyltransferase -
N0B28_RS22695 (N0B28_22710) 4980496..4982787 + 2292 WP_275728934.1 autotransporter domain-containing protein -
N0B28_RS22700 (N0B28_22715) 4982870..4983211 - 342 WP_043863853.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0B28_RS22705 (N0B28_22720) 4983211..4983459 - 249 WP_078481358.1 type II toxin-antitoxin system HicA family toxin Toxin
N0B28_RS22710 (N0B28_22725) 4983704..4984714 - 1011 WP_275728940.1 NAD(P)-dependent alcohol dehydrogenase -
N0B28_RS22715 (N0B28_22730) 4984856..4985356 + 501 WP_043863856.1 sigma-70 family RNA polymerase sigma factor -
N0B28_RS22720 (N0B28_22735) 4985358..4986305 + 948 WP_275728944.1 FecR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4964934..4983459 18525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-68)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9137.61 Da        Isoelectric Point: 10.5436

>T257085 WP_078481358.1 NZ_CP104044:c4983459-4983211 [Pseudomonas sp. SD17-1]
MSRHEKLLAKLSNKHSVFTWGELTALLSGFGYRQINGNGSRVKFDNGNPLAMINLHKPHPGNELKAYIRCQVIEHLKAGG
LI

Download         Length: 249 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12511.99 Da        Isoelectric Point: 6.4842

>AT257085 WP_043863853.1 NZ_CP104044:c4983211-4982870 [Pseudomonas sp. SD17-1]
MGTLLHYRGYHGSIEASPEDNCLYGKVQFIRALVSYEGETVAQLDAAFREAVDDYLHTCATLHQAPETPCKGSFNVRVGH
DLHLAASVVANRQSISLNDLTRRALTAYLSHHE

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1P013

References