257070

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 461..935 Replicon plasmid p2_150040X0B1
Accession NZ_CP104034
Organism Klebsiella pneumoniae strain 150040X0B1

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag N1940_RS28980 Protein ID WP_004197762.1
Coordinates 461..727 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag N1940_RS28985 Protein ID WP_000879771.1
Coordinates 711..935 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1940_RS28975 (N1940_28975) 41..391 + 351 WP_004197756.1 hypothetical protein -
N1940_RS28980 (N1940_28980) 461..727 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1940_RS28985 (N1940_28985) 711..935 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
N1940_RS28990 (N1940_28995) 1602..1814 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
N1940_RS28995 (N1940_29000) 1821..2330 - 510 WP_032433972.1 MbeB family mobilization protein -
N1940_RS29000 (N1940_29005) 2365..2799 - 435 Protein_5 relaxase/mobilization nuclease domain-containing protein -
N1940_RS29005 (N1940_29010) 3008..3352 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
N1940_RS29010 (N1940_29015) 3342..3518 - 177 WP_004197757.1 hypothetical protein -
N1940_RS29015 (N1940_29020) 4674..5000 + 327 WP_050516389.1 hypothetical protein -
N1940_RS29020 (N1940_29025) 5026..5571 + 546 WP_023317533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T257070 WP_004197762.1 NZ_CP104034:c727-461 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT257070 WP_000879771.1 NZ_CP104034:c935-711 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References