Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877740..878394 Replicon chromosome
Accession NZ_CP104030
Organism Klebsiella pneumoniae strain 150040X0B1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag N1940_RS04425 Protein ID WP_004144731.1
Coordinates 877987..878394 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag N1940_RS04420 Protein ID WP_002916312.1
Coordinates 877740..878006 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1940_RS04395 (N1940_04395) 872896..874329 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
N1940_RS04400 (N1940_04400) 874448..875176 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
N1940_RS04405 (N1940_04405) 875226..875537 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
N1940_RS04410 (N1940_04410) 875701..876360 + 660 WP_002916317.1 hemolysin III family protein -
N1940_RS04415 (N1940_04415) 876511..877494 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
N1940_RS04420 (N1940_04420) 877740..878006 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
N1940_RS04425 (N1940_04425) 877987..878394 + 408 WP_004144731.1 protein YgfX Toxin
N1940_RS04430 (N1940_04430) 878401..878922 - 522 WP_002916308.1 flavodoxin FldB -
N1940_RS04435 (N1940_04435) 879023..879919 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
N1940_RS04440 (N1940_04440) 879942..880655 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N1940_RS04445 (N1940_04445) 880661..882394 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T257044 WP_004144731.1 NZ_CP104030:877987-878394 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT257044 WP_002916312.1 NZ_CP104030:877740-878006 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References