257038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2684624..2685251 Replicon chromosome
Accession NZ_CP104025
Organism Erwinia amylovora strain Ea915

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag MTP51_RS12130 Protein ID WP_004156337.1
Coordinates 2685033..2685251 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MTP51_RS12125 Protein ID WP_013035913.1
Coordinates 2684624..2685013 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP51_RS12105 (MTP51_12105) 2679643..2682789 + 3147 WP_004156353.1 multidrug efflux RND transporter permease subunit AcrB -
MTP51_RS12110 (MTP51_12110) 2682937..2683218 + 282 WP_004156350.1 type B 50S ribosomal protein L31 -
MTP51_RS12115 (MTP51_12115) 2683206..2683352 + 147 WP_004156349.1 type B 50S ribosomal protein L36 -
MTP51_RS12120 (MTP51_12120) 2684124..2684477 + 354 WP_004156342.1 hypothetical protein -
MTP51_RS12125 (MTP51_12125) 2684624..2685013 + 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
MTP51_RS12130 (MTP51_12130) 2685033..2685251 + 219 WP_004156337.1 HHA domain-containing protein Toxin
MTP51_RS12140 (MTP51_12140) 2685551..2685868 + 318 WP_168397246.1 MGMT family protein -
MTP51_RS12145 (MTP51_12145) 2685891..2686448 - 558 WP_004156333.1 YbaY family lipoprotein -
MTP51_RS12150 (MTP51_12150) 2686673..2687533 + 861 WP_004156324.1 acyl-CoA thioesterase II -
MTP51_RS12155 (MTP51_12155) 2687608..2688909 - 1302 WP_004172214.1 ammonium transporter AmtB -
MTP51_RS12160 (MTP51_12160) 2688927..2689265 - 339 WP_004156319.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T257038 WP_004156337.1 NZ_CP104025:2685033-2685251 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT257038 WP_013035913.1 NZ_CP104025:2684624-2685013 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References