Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3042888..3043554 Replicon chromosome
Accession NZ_CP104022
Organism Erwinia amylovora strain Ea102

Toxin (Protein)


Gene name cptA Uniprot ID A0A830ZTB8
Locus tag MTP49_RS13790 Protein ID WP_004161808.1
Coordinates 3042888..3043307 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4HWC2
Locus tag MTP49_RS13795 Protein ID WP_004155593.1
Coordinates 3043288..3043554 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP49_RS13775 (MTP49_13775) 3038880..3040559 + 1680 WP_004155599.1 type III effector -
MTP49_RS13780 (MTP49_13780) 3041069..3042022 + 954 WP_004155597.1 DMT family transporter -
MTP49_RS13785 (MTP49_13785) 3042252..3042770 + 519 WP_004155596.1 flavodoxin FldB -
MTP49_RS13790 (MTP49_13790) 3042888..3043307 - 420 WP_004161808.1 protein YgfX Toxin
MTP49_RS13795 (MTP49_13795) 3043288..3043554 - 267 WP_004155593.1 FAD assembly factor SdhE Antitoxin
MTP49_RS13800 (MTP49_13800) 3043780..3044766 + 987 WP_004155590.1 tRNA-modifying protein YgfZ -
MTP49_RS13805 (MTP49_13805) 3044767..3045426 - 660 WP_004155588.1 hemolysin III family protein -
MTP49_RS13810 (MTP49_13810) 3045639..3046247 + 609 WP_004155587.1 HD domain-containing protein -
MTP49_RS13815 (MTP49_13815) 3046352..3047081 - 730 Protein_2654 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16366.46 Da        Isoelectric Point: 11.9444

>T257030 WP_004161808.1 NZ_CP104022:c3043307-3042888 [Erwinia amylovora]
VVLWQCELRPSRLAQRFSLLLHGAVMLALLLPTWPASSGLVRMLLLVLVLLECIRSRRRIGRRQGDIALLEGHELRWRQR
EWCIISRPWLTGQAILLLLQDTHGQRERLWLFADGMEKRNWRQLRLQLLNSKVQGNGWC

Download         Length: 420 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10498.07 Da        Isoelectric Point: 6.4605

>AT257030 WP_004155593.1 NZ_CP104022:c3043554-3043288 [Erwinia amylovora]
MDITNKSRIHWACRRGMRELDISIMPFFQYEFDSLNDSDKRLFVRLLESDDPDLFNWLMNHGEPADVELKRMVALIQQRN
KQRGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A830ZTB8

Antitoxin

Source ID Structure
AlphaFold DB A0A831A3F0

References