Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 135881..137603 Replicon chromosome
Accession NC_016445
Organism Vibrio cholerae O1 str. 2010EL-1786

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag HJ37_RS00580 Protein ID WP_000356587.1
Coordinates 136665..137603 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag HJ37_RS00575 Protein ID WP_000095578.1
Coordinates 135881..136672 (+) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HJ37_RS00545 131554..131835 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
HJ37_RS00550 131832..132458 + 627 WP_000667170.1 hypothetical protein -
HJ37_RS00555 132442..133338 + 897 WP_001911237.1 type-F conjugative transfer system secretin TraK -
HJ37_RS00560 133341..134630 + 1290 WP_000647305.1 TraB/VirB10 family protein -
HJ37_RS00565 134705..135277 + 573 WP_001944091.1 type IV conjugative transfer system lipoprotein TraV -
HJ37_RS00570 135274..135660 + 387 WP_000180223.1 hypothetical protein -
HJ37_RS00575 135881..136672 + 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
HJ37_RS00580 136665..137603 + 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
HJ37_RS00585 137735..138427 + 693 WP_001228926.1 DsbC family protein -
HJ37_RS00590 138427..140826 + 2400 WP_000648042.1 type IV secretion system protein TraC -
HJ37_RS00595 140819..141166 + 348 WP_001044650.1 hypothetical protein -
HJ37_RS00600 141150..141662 + 513 WP_001166558.1 S26 family signal peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element floR / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA1 - 78146..224562 146416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T25703 WP_000356587.1 NC_016445:136665-137603 [Vibrio cholerae O1 str. 2010EL-1786]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T25703 NC_016445:136665-137603 [Vibrio cholerae O1 str. 2010EL-1786]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT25703 WP_000095578.1 NC_016445:135881-136672 [Vibrio cholerae O1 str. 2010EL-1786]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT25703 NC_016445:135881-136672 [Vibrio cholerae O1 str. 2010EL-1786]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAAAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTTAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCGTAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References