257023

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2800318..2800847 Replicon chromosome
Accession NZ_CP104020
Organism Staphylococcus aureus strain 0831

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N0J69_RS13980 Protein ID WP_000621175.1
Coordinates 2800485..2800847 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag N0J69_RS13975 Protein ID WP_000948331.1
Coordinates 2800318..2800488 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0J69_RS13945 (2795355) 2795355..2795915 + 561 WP_001092411.1 K(+)-transporting ATPase subunit C -
N0J69_RS13950 (2796123) 2796123..2796602 + 480 WP_001287088.1 hypothetical protein -
N0J69_RS13955 (2796595) 2796595..2798178 + 1584 WP_001294626.1 PH domain-containing protein -
N0J69_RS13960 (2798165) 2798165..2798656 + 492 WP_001205910.1 PH domain-containing protein -
N0J69_RS13965 (2798660) 2798660..2799019 + 360 WP_000581200.1 holo-ACP synthase -
N0J69_RS13970 (2799085) 2799085..2800233 + 1149 WP_001281145.1 alanine racemase -
N0J69_RS13975 (2800318) 2800318..2800488 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
N0J69_RS13980 (2800485) 2800485..2800847 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N0J69_RS13985 (2801197) 2801197..2802198 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
N0J69_RS13990 (2802317) 2802317..2802643 + 327 WP_001052491.1 anti-sigma factor antagonist -
N0J69_RS13995 (2802645) 2802645..2803124 + 480 WP_001190829.1 anti-sigma B factor RsbW -
N0J69_RS14000 (2803099) 2803099..2803869 + 771 WP_001041103.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T257023 WP_000621175.1 NZ_CP104020:2800485-2800847 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT257023 WP_000948331.1 NZ_CP104020:2800318-2800488 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References