257022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2780577..2781091 Replicon chromosome
Accession NZ_CP104020
Organism Staphylococcus aureus strain 0831

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag N0J69_RS13890 Protein ID WP_000581792.1
Coordinates 2780882..2781091 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag N0J69_RS13885 Protein ID WP_000138932.1
Coordinates 2780577..2780870 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0J69_RS13865 (2775840) 2775840..2776481 + 642 WP_000483153.1 thiamine phosphate synthase -
N0J69_RS13870 (2776567) 2776567..2777439 + 873 WP_000725802.1 membrane protein insertase YidC -
N0J69_RS13875 (2778252) 2778252..2778899 - 648 WP_001187629.1 HD domain-containing protein -
N0J69_RS13880 (2778927) 2778927..2780411 - 1485 WP_000571549.1 cardiolipin synthase -
N0J69_RS13885 (2780577) 2780577..2780870 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
N0J69_RS13890 (2780882) 2780882..2781091 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
N0J69_RS13895 (2781219) 2781219..2781356 + 138 WP_000828354.1 Lmo0850 family protein -
N0J69_RS13900 (2781620) 2781620..2782822 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
N0J69_RS13905 (2783140) 2783140..2784210 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
N0J69_RS13910 (2784225) 2784225..2785583 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T257022 WP_000581792.1 NZ_CP104020:2780882-2781091 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT257022 WP_000138932.1 NZ_CP104020:2780577-2780870 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References