Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2338507..2340101 Replicon chromosome
Accession NZ_CP104014
Organism Enterobacter sp. CP102

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N1249_RS11045 Protein ID WP_259837781.1
Coordinates 2338776..2340101 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N1249_RS11040 Protein ID WP_259837779.1
Coordinates 2338507..2338776 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1249_RS11015 (N1249_11015) 2333903..2334391 - 489 WP_259837768.1 ATP-binding protein -
N1249_RS11020 (N1249_11020) 2334493..2334846 + 354 WP_259837770.1 hypothetical protein -
N1249_RS11025 (N1249_11025) 2334988..2336280 + 1293 WP_259837773.1 glycosyl hydrolase family 28 protein -
N1249_RS11030 (N1249_11030) 2336302..2337291 - 990 WP_259837775.1 zinc-dependent alcohol dehydrogenase family protein -
N1249_RS11035 (N1249_11035) 2337408..2338310 - 903 WP_259837777.1 LysR family transcriptional regulator -
N1249_RS11040 (N1249_11040) 2338507..2338776 + 270 WP_259837779.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N1249_RS11045 (N1249_11045) 2338776..2340101 + 1326 WP_259837781.1 type II toxin-antitoxin system HipA family toxin Toxin
N1249_RS11050 (N1249_11050) 2340139..2340501 - 363 WP_259837783.1 DUF4406 domain-containing protein -
N1249_RS11055 (N1249_11055) 2340688..2341569 - 882 WP_259837785.1 SDR family oxidoreductase -
N1249_RS11060 (N1249_11060) 2341636..2342025 - 390 WP_259837787.1 YdeI family stress tolerance OB fold protein -
N1249_RS11065 (N1249_11065) 2342165..2342668 + 504 WP_259837789.1 hypothetical protein -
N1249_RS11070 (N1249_11070) 2342678..2343139 + 462 WP_259837792.1 DUF421 domain-containing protein -
N1249_RS11075 (N1249_11075) 2343404..2343838 + 435 WP_259837794.1 nuclear transport factor 2 family protein -
N1249_RS11080 (N1249_11080) 2343835..2344554 + 720 WP_259837796.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49293.33 Da        Isoelectric Point: 7.2085

>T257003 WP_259837781.1 NZ_CP104014:2338776-2340101 [Enterobacter sp. CP102]
MPKLVTWMNNERVGELTKLTNGAHTFKYANEWLLNRYARPLSLSLPLQFGEITSDAVFNFFDNLLPDSPAVRDRIVKRYH
ARSRQPFDLLAEVGRDSVGAVTLLPANENSTTPEMTWETLSEEKLETVLTAYQSDIPLGMINEENDFRISVAGAQEKTAL
LKAGDDWCIPKGITPTTHIIKLPIGEIKQPNATLDLSDSVDNEYFCLQLARALRFDVPNAEIIRAGRVRALAVERFDRRW
NASRSVLLRLPQEDMCQTFGLPSSVKYESDGGPGIPHIMAFLLGSSEALTDRYNFMKFQLFQWITGATDGHAKNFSIFIQ
PGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMSLNASKGRKNDIDKIYPRHFMATARAVRFPENQMTGIMQEFIDHVP
QALDTVMSSLPTDFSQKVATSIYKNVLRLHGRLSKSAGGST

Download         Length: 1326 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10212.51 Da        Isoelectric Point: 6.2341

>AT257003 WP_259837779.1 NZ_CP104014:2338507-2338776 [Enterobacter sp. CP102]
MKPPMIYSPVQLANTMRLVRQKNNWTQSDLAKRIGIKQATISNFENNPDNTTLTTFFRILQSLEMTMALYEKDDTASGSD
NNNQQGLDW

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References