Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1086346..1086967 Replicon chromosome
Accession NZ_CP104014
Organism Enterobacter sp. CP102

Toxin (Protein)


Gene name Hha Uniprot ID A0A198GT90
Locus tag N1249_RS05090 Protein ID WP_014069157.1
Coordinates 1086346..1086564 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag N1249_RS05095 Protein ID WP_008499288.1
Coordinates 1086593..1086967 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1249_RS05060 (N1249_05060) 1082356..1082616 + 261 WP_014069152.1 type B 50S ribosomal protein L31 -
N1249_RS05065 (N1249_05065) 1082619..1082759 + 141 WP_006818844.1 type B 50S ribosomal protein L36 -
N1249_RS05070 (N1249_05070) 1082756..1083466 - 711 WP_259835026.1 GNAT family protein -
N1249_RS05075 (N1249_05075) 1083566..1085026 + 1461 WP_259835028.1 PLP-dependent aminotransferase family protein -
N1249_RS05080 (N1249_05080) 1084998..1085465 - 468 WP_259835030.1 YlaC family protein -
N1249_RS05085 (N1249_05085) 1085582..1086133 - 552 WP_259835031.1 maltose O-acetyltransferase -
N1249_RS05090 (N1249_05090) 1086346..1086564 - 219 WP_014069157.1 HHA domain-containing protein Toxin
N1249_RS05095 (N1249_05095) 1086593..1086967 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
N1249_RS05100 (N1249_05100) 1087481..1090627 - 3147 WP_259835033.1 multidrug efflux RND transporter permease subunit AcrB -
N1249_RS05105 (N1249_05105) 1090650..1091843 - 1194 WP_259835034.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8579.94 Da        Isoelectric Point: 8.9008

>T257001 WP_014069157.1 NZ_CP104014:c1086564-1086346 [Enterobacter sp. CP102]
MSDKPLTKIDYLLRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT257001 WP_008499288.1 NZ_CP104014:c1086967-1086593 [Enterobacter sp. CP102]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A198GT90

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References