Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 151036..151640 Replicon chromosome
Accession NZ_CP104014
Organism Enterobacter sp. CP102

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N1249_RS00730 Protein ID WP_259833781.1
Coordinates 151036..151221 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N1249_RS00735 Protein ID WP_259833783.1
Coordinates 151236..151640 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1249_RS00710 (N1249_00710) 146104..147255 + 1152 WP_259833774.1 L-threonine dehydrogenase -
N1249_RS00715 (N1249_00715) 147341..148879 + 1539 WP_014068390.1 aldehyde dehydrogenase AldB -
N1249_RS00720 (N1249_00720) 148876..149838 - 963 WP_259833777.1 LysR family transcriptional regulator -
N1249_RS00725 (N1249_00725) 149959..150699 + 741 WP_259833779.1 MipA/OmpV family protein -
N1249_RS00730 (N1249_00730) 151036..151221 + 186 WP_259833781.1 type II toxin-antitoxin system HicA family toxin Toxin
N1249_RS00735 (N1249_00735) 151236..151640 + 405 WP_259833783.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N1249_RS00740 (N1249_00740) 151684..153633 - 1950 WP_259833785.1 glycoside hydrolase family 127 protein -
N1249_RS00745 (N1249_00745) 153644..155044 - 1401 WP_259833787.1 MFS transporter -
N1249_RS00750 (N1249_00750) 155269..156093 + 825 WP_259833789.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6901.15 Da        Isoelectric Point: 11.2509

>T256999 WP_259833781.1 NZ_CP104014:151036-151221 [Enterobacter sp. CP102]
VKSADVITILVSHGWKCIRTKGSHHQFRHPVYKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14890.74 Da        Isoelectric Point: 4.3841

>AT256999 WP_259833783.1 NZ_CP104014:151236-151640 [Enterobacter sp. CP102]
MFYPAYIHSDLNGSASGFFPDVPGCFFAGDSLDDAFQDARAALTAHFEALFESEEELPLPGNVEAHLEATPADFIGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References