Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4327009..4327627 Replicon chromosome
Accession NZ_CP104006
Organism Yersinia alsatica strain SCPM-O-B-7604

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag N0H69_RS19595 Protein ID WP_002208622.1
Coordinates 4327424..4327627 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A857F2E4
Locus tag N0H69_RS19590 Protein ID WP_004392643.1
Coordinates 4327009..4327377 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0H69_RS19560 (N0H69_19560) 4322680..4322940 + 261 WP_050077358.1 type B 50S ribosomal protein L31 -
N0H69_RS19565 (N0H69_19565) 4322956..4323099 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
N0H69_RS19570 (N0H69_19570) 4323228..4324106 - 879 WP_050151542.1 metal ABC transporter substrate-binding protein -
N0H69_RS19575 (N0H69_19575) 4324135..4324992 - 858 WP_050151544.1 metal ABC transporter permease -
N0H69_RS19580 (N0H69_19580) 4324989..4325723 - 735 WP_050133694.1 ABC transporter ATP-binding protein -
N0H69_RS19585 (N0H69_19585) 4326497..4326850 + 354 WP_050108920.1 hypothetical protein -
N0H69_RS19590 (N0H69_19590) 4327009..4327377 + 369 WP_004392643.1 Hha toxicity modulator TomB Antitoxin
N0H69_RS19595 (N0H69_19595) 4327424..4327627 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
N0H69_RS19600 (N0H69_19600) 4328429..4328770 + 342 WP_050151547.1 metalloregulator ArsR/SmtB family transcription factor -
N0H69_RS19605 (N0H69_19605) 4329089..4330378 + 1290 WP_050151549.1 arsenic transporter -
N0H69_RS19610 (N0H69_19610) 4330457..4330885 + 429 WP_050151551.1 glutaredoxin-dependent arsenate reductase -
N0H69_RS19615 (N0H69_19615) 4330976..4331479 + 504 WP_050151553.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T256990 WP_002208622.1 NZ_CP104006:4327424-4327627 [Yersinia alsatica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14176.95 Da        Isoelectric Point: 4.5140

>AT256990 WP_004392643.1 NZ_CP104006:4327009-4327377 [Yersinia alsatica]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A857F2E4

References