Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4327009..4327627 Replicon chromosome
Accession NZ_CP104006
Organism Yersinia alsatica strain SCPM-O-B-7604

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag N0H69_RS19595 Protein ID WP_002208622.1
Coordinates 4327424..4327627 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A857F2E4
Locus tag N0H69_RS19590 Protein ID WP_004392643.1
Coordinates 4327009..4327377 (+) Length 123 a.a.

Genomic Context

N0H69_RS19560N0H69_RS19565N0H69_RS19585N0H69_RS19590N0H69_RS19595N0H69_RS19600N0H69_RS19605N0H69_RS19610N0H69_RS19615N0H69_RS19570N0H69_RS19575N0H69_RS19580
Location: 4322680..4322940 (261 bp)
Type: Others
Protein ID: WP_050077358.1
Location: 4322956..4323099 (144 bp)
Type: Others
Protein ID: WP_002208618.1
Location: 4326497..4326850 (354 bp)
Type: Others
Protein ID: WP_050108920.1
Location: 4327009..4327377 (369 bp)
Type: Antitoxin
Protein ID: WP_004392643.1
Location: 4327424..4327627 (204 bp)
Type: Toxin
Protein ID: WP_002208622.1
Location: 4328429..4328770 (342 bp)
Type: Others
Protein ID: WP_050151547.1
Location: 4329089..4330378 (1290 bp)
Type: Others
Protein ID: WP_050151549.1
Location: 4330457..4330885 (429 bp)
Type: Others
Protein ID: WP_050151551.1
Location: 4330976..4331479 (504 bp)
Type: Others
Protein ID: WP_050151553.1
Location: 4323228..4324106 (879 bp)
Type: Others
Protein ID: WP_050151542.1
Location: 4324135..4324992 (858 bp)
Type: Others
Protein ID: WP_050151544.1
Location: 4324989..4325723 (735 bp)
Type: Others
Protein ID: WP_050133694.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N0H69_RS19560 (N0H69_19560)4322680..4322940+261WP_050077358.1type B 50S ribosomal protein L31-
N0H69_RS19565 (N0H69_19565)4322956..4323099+144WP_002208618.1type B 50S ribosomal protein L36-
N0H69_RS19570 (N0H69_19570)4323228..4324106-879WP_050151542.1metal ABC transporter substrate-binding protein-
N0H69_RS19575 (N0H69_19575)4324135..4324992-858WP_050151544.1metal ABC transporter permease-
N0H69_RS19580 (N0H69_19580)4324989..4325723-735WP_050133694.1ABC transporter ATP-binding protein-
N0H69_RS19585 (N0H69_19585)4326497..4326850+354WP_050108920.1hypothetical protein-
N0H69_RS19590 (N0H69_19590)4327009..4327377+369WP_004392643.1Hha toxicity modulator TomBAntitoxin
N0H69_RS19595 (N0H69_19595)4327424..4327627+204WP_002208622.1expression modulating protein YmoAToxin
N0H69_RS19600 (N0H69_19600)4328429..4328770+342WP_050151547.1metalloregulator ArsR/SmtB family transcription factor-
N0H69_RS19605 (N0H69_19605)4329089..4330378+1290WP_050151549.1arsenic transporter-
N0H69_RS19610 (N0H69_19610)4330457..4330885+429WP_050151551.1glutaredoxin-dependent arsenate reductase-
N0H69_RS19615 (N0H69_19615)4330976..4331479+504WP_050151553.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T256990 WP_002208622.1 NZ_CP104006:4327424-4327627 [Yersinia alsatica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14176.95 Da        Isoelectric Point: 4.5140

>AT256990 WP_004392643.1 NZ_CP104006:4327009-4327377 [Yersinia alsatica]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB2K5S

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A857F2E4

References